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| Management and evaluation of bladder paragangliomas |
Sagar Patel( ),Judy Hamad,Matthew E. Nielsen,Steven Johnson
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| System Ringgold Standard Institution, University of North Carolina, Chapel Hill, NC, United States |
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Abstract Extraadrenal paragangliomas are tumors composed of neuroendocrine-derived, catecholamine-secreting chromaffin cells inducing hypertension, palpitations, and diaphoresis [1]. Although extraadrenal paragangliomas are found in a variety of anatomic sites that normally host paraganglia—from the carotid body to the abdominal paraaortic region—the bladder is an uncommon location for paragangliomas. Bladder paragangliomas represent approximately 6% of extraadrenal paragangliomas and only 0.05% of all bladder tumors [2,3]. We present a rare case of primary paraganglioma affecting the bladder dome.
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Received: 26 July 2020
Available online: 20 January 2022
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Corresponding Authors:
Sagar Patel
E-mail: sagar.patel@bcm.edu
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Abdomen and pelvis computed tomography of bladder paraganglioma. (A) Coronal image; (B) Sagittal cross-sectional image. The white arrow shows the tumor.
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Histopathologic features of bladder paraganglioma. Histology images showed tumor underlying normal bladder mucosa (A, 4x original magnification) and infiltrating between detrusor muscle bundles (B, 4x). This case showed the classic zellballen or nested cellular arrangement with a surrounding delicate vascular network (C, 10x). Neoplastic cells (D, 40x) were round to polygonal and showed clear to amphophilic granular cytoplasm and strong immunoreactivity for synaptophysin (E, 40x) and chromogranin (F, 40x).
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