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| Expanding luminal epitheliums as cells of origin for prostate cancer |
Yuexi Gua,b,*( ),Gong-Hong Weia,b,c,*()
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a Fudan University Shanghai Cancer Center, Department of Biochemistry and Molecular Biology, School of Basic
b Medical Sciences, Shanghai Medical College of Fudan University, Shanghai, China
c Biocenter Oulu and Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland |
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Available online: 20 April 2021
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Corresponding Authors:
Yuexi Gu,Gong-Hong Wei
E-mail: gu-yuexi@hotmail.com;gonghong_wei@fudan.edu.cn
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Tacstd2+ L2/Luminal-C cells have stemness properties and can serve as cells of origin for prostate cancer. Tacstd2+ Luminal-C cells are localized to the invagination tips of prostate distal regions, whereas in the proximal region, they form a continuous luminal layer. ① Tacstd2+ Luminal-C cells isolated from both proximal and distal regions can form organoids that have both luminal and basal epithelial cells. ② Prostate gland reconstructed from Luminal-C cells by grafting contains both luminal and basal cell markers, and Tacstd2+ Luminal-C cells are confined to the invagination tips of the regenerated gland. ③ Tacstd2+ Luminal-C cells isolated from prostate distal regions have the capacity of self-renewal and differentiation into Tacstd2- luminal cells. ④ Dist-Luminal-C cells initiate prostate cancer after lineage-specific deletion of the tumor suppressor gene Pten (dashed rectangle). ⑤ Growth factors secreted by mesenchymal cells support luminal cell growth. Fgf10, fibroblast growth factor 10; Igf1, insulin-like growth factor 1; Nrg2, neuregulin 2.
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