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Asian Journal of Urology, 2019, 6(1): 3-9    doi: 10.1016/j.ajur.2018.10.001
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Current progress and questions in germline genetics of prostate cancer
William B. Isaacsa,*(),Jianfeng Xub
a Brady Urological Institute, Johns Hopkins University, School of Medicine, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA
b North Shore University Health System, Research Institute, Evanston, IL, USA
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Abstract  

Dramatic progress has been made in the area of germline genetics of prostate cancer (PCa) in the past decade. Both common and rare genetic variants with effects on risk ranging from barely detectable to outright practice-changing have been identified. For men with high risk PCa, the application of genetic testing for inherited pathogenic mutations is becoming standard of care. A major question exists about which additional populations of men to test, as men at all risk levels can potentially benefit by knowing their unique genetic profile of germline susceptibility variants. This article will provide a brief overview of some current issues in understanding inherited susceptibility for PCa.

Key wordsGenetic susceptibility      BRCA2      Single-nucleotide polymorphisms      Mutations      Germline genetics      Prostate cancer     
Received: 10 July 2018      Available online: 02 November 2018
Corresponding Authors: William B. Isaacs     E-mail: wisaacs@jhmi.edu
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William B. Isaacs
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William B. Isaacs,Jianfeng Xu. Current progress and questions in germline genetics of prostate cancer[J]. Asian Journal of Urology, 2019, 6(1): 3-9.
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http://www.ajurology.com/EN/10.1016/j.ajur.2018.10.001     OR     http://www.ajurology.com/EN/Y2019/V6/I1/3