The aging bladder insights from animal models

doi:10.1016/j.ajur.2017.03.004

Asian Journal of Urology, 2018, 5 (3): 135-140 doi: 10.1016/j.ajur.2017.03.004

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The aging bladder insights from animal models

Lori A.Birder^a^b,Aura F.Kullmann^b,Christopher R.Chapple^c^*(

)

a University of Pittsburgh School of Medicine, Department of Pharmacology, Pittsburgh, PA, USA

b University of Pittsburgh School of Medicine, Department of Medicine, Pittsburgh, PA, USA

c Department of Urology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK

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Abstract

Alterations in bladder function with aging are very common and are very likely to represent an increasing healthcare problem in the years to come with the general aging of the population. In this review the authors describe the prevalence of lower urinary tract symptoms (LUTS) and comment upon potential mechanisms which may be responsible for the increasing prevalence of lower LUTS with increasing age, based on laboratory studies. It is clear that there is a complex interplay between the various components of the neural innervation structure of the bladder in leading to changes with age, which are likely to underpin the LUTS which are seen in the aging bladder.

Key words： Lower urinary tract symptoms Aging Etiology of lower urinary tract symptoms Bladder function

Received: 10 March 2017 Published: 23 July 2018

Corresponding Authors: R.Chapple Christopher E-mail: c.r.chapple@shef.ac.uk

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A.Birder Lori,F.Kullmann Aura,R.Chapple Christopher. The aging bladder insights from animal models[J]. Asian Journal of Urology, 2018, 5(3): 135-140.

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http://www.ajurology.com/EN/10.1016/j.ajur.2017.03.004 OR http://www.ajurology.com/EN/Y2018/V5/I3/135

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