Underactive bladder: Pathophysiology and clinical significance

doi:10.1016/j.ajur.2017.02.003

Asian Journal of Urology, 2018, 5 (1): 17-21 doi: 10.1016/j.ajur.2017.02.003

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Underactive bladder: Pathophysiology and clinical significance

Aldamanhori Reem^a,I.Osman Nadir^b,R.Chapple Christopher^b

^a Department of Urology, University of Dammam, Saudi Arabia
^b Department of Urology, Royal Hallamshire Hospital, Sheffield, UK

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Abstract

Underactive bladder (UAB) is a voiding disorder which generates disabling lower urinary tract symptoms (LUTS) due to the inability to produce an effective voiding contraction sufficient to empty the bladder. The underlying abnormality, that is usually appreciated when performing urodynamic studies, has been defined by the International Continence Society (ICS) as detrusor underactivity (DUA). DUA is a common yet under-researched bladder dysfunction. The prevalence of DUA in different patient groups suggests that multiple aetiologies are implicated. Currently there is no effective therapeutic approach to treat this condition. An improved understanding of the underlying mechanisms is needed to facilitate the development of new advances in treatment. The purpose of this review is to discuss the epidemiology, pathophysiology, common causes and risk factors potentially leading to DUA; to aid in the appropriate diagnosis of DUA to potentially improve treatment outcomes.

Key words： Detrusor underactivity Lower urinary tract symptoms Underactive bladder Bladder outlet obstruction

Received: 18 September 2016 Published: 07 March 2018

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Aldamanhori Reem,I.Osman Nadir,R.Chapple Christopher. Underactive bladder: Pathophysiology and clinical significance[J]. Asian Journal of Urology, 2018, 5(1): 17-21.

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http://www.ajurology.com/EN/10.1016/j.ajur.2017.02.003 OR http://www.ajurology.com/EN/Y2018/V5/I1/17

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