Evaluation of kidney allograft status using novel ultrasonic technologies

Asian Journal of Urology, 2015, 2 (3): 142-150 doi:

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Evaluation of kidney allograft status using novel ultrasonic technologies

Cheng Yang¹, Mushuang Hu¹, Tongyu Zhu¹, Wanyuan He²

1 Department of Urology, Zhongshan Hospital, Fudan University, Shanghai Key Laboratory of Organ Transplantation, Shanghai, China;
2 Department of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai Institute of Imaging Medicine, Shanghai, China

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Abstract Early diagnosis of kidney allograft injury contributes to proper decisions regarding treatment strategy and promotes the long-term survival of both the recipients and the allografts. Although biopsy remains the gold standard, non-invasive methods of kidney allograft evaluation are required for clinical practice. Recently, novel ultrasonic technologies have been applied in the evaluation and diagnosis of kidney allograft status, including tissue elasticity quantification using acoustic radiation force impulse (ARFI) and contrast-enhanced ultrasonography (CEUS). In this review, we discuss current opinions on the application of ARFI and CEUS for evaluating kidney allograft function and their possible influencing factors, advantages and limitations. We also compare these two technologies with other non-invasive diagnostic methods, including nuclear medicine and radiology. While the role of novel non-invasive ultrasonic technologies in the assessment of kidney allografts requires further investigation, the use of such technologies remains highly promising.

Key words： Ultrasound Acoustic radiation force impulse Contrast-enhanced ultrasonography Kidney transplantation Non-invasive

Received: 26 June 2015 Published: 18 September 2015

Fund:This study was supported by the Science and Technology Commission of Shanghai Municipality (13ZR1406400, 15411964900 to Wanyuan He) and the National Natural Science Foundation of China (81270833 to Tongyu Zhu; 81400752 to Cheng Yang).

Corresponding Authors: Wanyuan He E-mail: he.wanyuan@zs-hospital.sh.cn,wanyuanhe@126.com

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Cheng Yang,Mushuang Hu,Tongyu Zhu, et al. Evaluation of kidney allograft status using novel ultrasonic technologies[J]. Asian Journal of Urology, 2015, 2(3): 142-150.

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http://www.ajurology.com/EN/ OR http://www.ajurology.com/EN/Y2015/V2/I3/142

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