Major histocompatibility complex I upregulation in clear cell renal cell carcinoma is associated with increased survival

doi:10.1016/j.ajur.2016.02.001

Asian Journal of Urology, 2016, 3 (2): 75-81 doi: 10.1016/j.ajur.2016.02.001

Original Article

Major histocompatibility complex I upregulation in clear cell renal cell carcinoma is associated with increased survival

Rishi R. Sekar^a, Claire M. De La Calle^a, Dattatraya Patil^a, Sarah A. Holzman^a, Yoram Baum^a, Umer Sheikh^b, Jonathan H. Huang^a, Adeboye O. Osunkoya^a,b,d, Brian P. Pollack^b,c,d, Haydn T. Kissick^a, Kenneth Ogan^a, Viraj A. Master^a

a Department of Urology, Emory University School of Medicine, Atlanta, GA, USA;
b Department of Pathology, Emory University School of Medicine, Atlanta, GA, USA;
c Department of Dermatology, Emory University School of Medicine, Atlanta, GA, USA;
d The Atlanta VA Medical Center, Decatur, GA, USA

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Abstract Objective: To examine the prognostic value of tumor major histocompatibility complex I (MHCI) expression on survival and recurrence in patients with clear cell renal cell carcinoma (RCC).
Methods: Fifty-three patients that underwent nephrectomy at our institution for clear cell RCC (T1-T3) with ≥ 4 years of follow-up were queried from our nephrectomy database. Immunohistochemical staining for MHCI was performed on tumor specimens and MHCI expression was quantified with an automated image analysis technique. Patients were divided into high and low MHCI expression groups in order to study the relationship between MHCI expression and prognosis using the Kaplan-Meier method and log-rank test.
Results: Overall survival and recurrence free survival were increased in the high MHCI expression group compared to the low MHCI expression group (log-rank, p=0.036 and p=0.028, respectively). Patients alive at the end of the study had higher MHCI expression (mean positivity score 0.82) than those that died of disease (mean positivity score 0.76, t test, p=0.030). Patients that did not develop recurrence during the study period had higher MHCI expression (mean positivity score 0.83) than those that did develop recurrence (mean positivity score 0.78), but this difference was not significant (t test, p=0.079).
Conclusion: Our data demonstrate that high MHCI expression confers improved overall and recurrence free survival in patients with clear cell RCC and could serve as an important prognostic tool in identifying high-risk patients.

Key words： Renal cell carcinoma Prognosis MHCI Biomarker

Received: 10 December 2015 Published: 13 May 2016

Corresponding Authors: Viraj A. Master E-mail: vmaster@emory.edu

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	Rishi R. Sekar
	Claire M. De La Calle
	Dattatraya Patil
	Sarah A. Holzman
	Yoram Baum
	Umer Sheikh
	Jonathan H. Huang
	Adeboye O. Osunkoya
	Brian P. Pollack
	Haydn T. Kissick
	Kenneth Ogan
	Viraj A. Master

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Cite this article:

Rishi R. Sekar,Claire M. De La Calle,Dattatraya Patil, et al. Major histocompatibility complex I upregulation in clear cell renal cell carcinoma is associated with increased survival[J]. Asian Journal of Urology, 2016, 3(2): 75-81.

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http://www.ajurology.com/EN/10.1016/j.ajur.2016.02.001 OR http://www.ajurology.com/EN/Y2016/V3/I2/75

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