The influence of asymptomatic inflammatory prostatitis on the onset and progression of lower urinary tract symptoms in men with histologic benign prostatic hyperplasia

doi:10.1016/j.ajur.2017.02.004

Asian Journal of Urology, 2017, 4 (3): 158-163 doi: 10.1016/j.ajur.2017.02.004

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The influence of asymptomatic inflammatory prostatitis on the onset and progression of lower urinary tract symptoms in men with histologic benign prostatic hyperplasia

Rikiya Taoka, Yoshiyuki Kakehi

Department of Urology, Faculty of Medicine, Kagawa University, Takamatsu, Kagawa, Japan

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Abstract Benign prostatic hyperplasia (BPH) is a condition that greatly affects the quality of life of middle-aged and elderly men. Histopathologically, hyperplastic changes frequently occur in the prostate tissue of elderly men, the incidence of which has been reported to reach approximately 80% in men in their 70s. In clinical practice, approximately 25% of men with histologic BPH are assumed to experience lower urinary tract symptoms (LUTS) and receive some kind of treatment. In other words, there are some men with histologic BPH who do not exhibit LUTS. For that reason, many factors, such as the change in hormonal environment, the immune or autoimmune response, the alteration of gene expression, and so on, are thought to affect the onset and progression of LUTS in men with histologic BPH. One such factor that has long drawn attention is the presence of asymptomatic histological inflammation, which very often accompanies symptomatic BPH. Recent studies have suggested that asymptomatic histological inflammation causes repeated destruction, healing, and regeneration of the prostate tissue, leading to the enlargement of prostatic nodules, while at the same time causing stromal tissuepredominant remodeling of the prostate tissue, which can increase urination resistance and result in the condition changing from asymptomatic BPH to symptomatic BPH. In future, the biomolecular clarification of the significance of asymptomatic histological inflammation in the prostate tissue could help develop new treatment strategies for BPH accompanied by LUTS.

Key words： Benign prostatic hyperplasia Asymptomatic histological inflammation Prostatitis Lower urinary tract symptoms

Received: 31 October 2016 Published: 26 August 2017

Corresponding Authors: Rikiya Taoka,E-mail address:rikiya@med.kagawa-u.ac.jp. E-mail: rikiya@med.kagawa-u.ac.jp

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Rikiya Taoka,Yoshiyuki Kakehi. The influence of asymptomatic inflammatory prostatitis on the onset and progression of lower urinary tract symptoms in men with histologic benign prostatic hyperplasia[J]. Asian Journal of Urology, 2017, 4(3): 158-163.

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http://www.ajurology.com/EN/10.1016/j.ajur.2017.02.004 OR http://www.ajurology.com/EN/Y2017/V4/I3/158