1 Department of Urology, Zhongshan Hospital, Fudan University, Shanghai Key Laboratory of Organ Transplantation, Shanghai, China;
2 Department of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai Institute of Imaging Medicine, Shanghai, China
Evaluation of kidney allograft status using novel ultrasonic technologies
1 Department of Urology, Zhongshan Hospital, Fudan University, Shanghai Key Laboratory of Organ Transplantation, Shanghai, China;
2 Department of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai Institute of Imaging Medicine, Shanghai, China
摘要 Early diagnosis of kidney allograft injury contributes to proper decisions regarding treatment strategy and promotes the long-term survival of both the recipients and the allografts. Although biopsy remains the gold standard, non-invasive methods of kidney allograft evaluation are required for clinical practice. Recently, novel ultrasonic technologies have been applied in the evaluation and diagnosis of kidney allograft status, including tissue elasticity quantification using acoustic radiation force impulse (ARFI) and contrast-enhanced ultrasonography (CEUS). In this review, we discuss current opinions on the application of ARFI and CEUS for evaluating kidney allograft function and their possible influencing factors, advantages and limitations. We also compare these two technologies with other non-invasive diagnostic methods, including nuclear medicine and radiology. While the role of novel non-invasive ultrasonic technologies in the assessment of kidney allografts requires further investigation, the use of such technologies remains highly promising.
Abstract: Early diagnosis of kidney allograft injury contributes to proper decisions regarding treatment strategy and promotes the long-term survival of both the recipients and the allografts. Although biopsy remains the gold standard, non-invasive methods of kidney allograft evaluation are required for clinical practice. Recently, novel ultrasonic technologies have been applied in the evaluation and diagnosis of kidney allograft status, including tissue elasticity quantification using acoustic radiation force impulse (ARFI) and contrast-enhanced ultrasonography (CEUS). In this review, we discuss current opinions on the application of ARFI and CEUS for evaluating kidney allograft function and their possible influencing factors, advantages and limitations. We also compare these two technologies with other non-invasive diagnostic methods, including nuclear medicine and radiology. While the role of novel non-invasive ultrasonic technologies in the assessment of kidney allografts requires further investigation, the use of such technologies remains highly promising.
基金资助: This study was supported by the Science and Technology Commission of Shanghai Municipality (13ZR1406400, 15411964900 to Wanyuan He) and the National Natural Science Foundation of China (81270833 to Tongyu Zhu; 81400752 to Cheng Yang).
通讯作者:
Wanyuan He
E-mail: he.wanyuan@zs-hospital.sh.cn,wanyuanhe@126.com
引用本文:
Cheng Yang, Mushuang Hu, Tongyu Zhu, Wanyuan He. Evaluation of kidney allograft status using novel ultrasonic technologies[J]. Asian Journal of Urology, 2015, 2(3): 142-150.
Cheng Yang, Mushuang Hu, Tongyu Zhu, Wanyuan He. Evaluation of kidney allograft status using novel ultrasonic technologies. Asian Journal of Urology, 2015, 2(3): 142-150.
Torres Munoz A, Valdez-Ortiz R, Gonzalez-Parra C, Espinoza-Davila E, Morales-Buenrostro LE, Correa-Rotter R. Percutaneous renal biopsy of native kidneys:efficiency, safety and risk factors associated with major complications. Arch Med Sci 2011;7:823-31.
[2]
McArthur C, Geddes CC, Baxter GM. Early measurement of pulsatility and resistive indexes:correlation with long-term renal transplant function. Radiology 2011;259:278-85.
[3]
Goya C, Hamidi C, Hattapoglu S, Cetincakmak MG, Teke M, Degirmenci MS, et al. Use of acoustic radiation force impulse elastography to diagnose acute pancreatitis at hospital admission:comparison with sonography and computed tomography. J Ultrasound Med 2014;33:1453-30.
[4]
Park MK, Jo J, Kwon H, Cho JH, Oh JY, Noh MH, et al. Usefulness of acoustic radiation force impulse elastography in the differential diagnosis of benign and malignant solid pancreatic lesions. Ultrasonography 2014;33:26-63.
[5]
Wu YM, Xu N, Hu JY, Xu XF, Wu WX, Gao SX, et al. A simple noninvasive index to predict significant liver fibrosis in patients with advanced schistosomiasis japonica. Parasitol Int 2013;62:283-3.
[6]
Ozkan F, Menzilcioglu MS, Duymus M, Yildiz S, Avcu S. Acoustic radiation force impulse elastography for evaluating renal parenchymal stiffness in children. Pediatr Radiol 2015;45:461.
[7]
Takahashi H, Ono N, Eguchi Y, Eguchi T, Kitajima Y, Kawaguchi Y, et al. Evaluation of acoustic radiation force impulse elastography for fibrosis staging of chronic liver disease:a pilot study. Liver Int 2010;30:538-85.
[8]
Stock KF, Klein BS, Vo Cong MT, Sarkar O, Romisch M, Regenbogen C, et al. ARFI-based tissue elasticity quantification in comparison to histology for the diagnosis of renal transplant fibrosis. Clin Hemorheol Microcirc 2010;46:139-98.
[9]
Syversveen T, Brabrand K, Midtvedt K, Strom EH, Hartmann A, Jakobsen JA, et al. Assessment of renal allograft fibrosis by acoustic radiation force impulse quantificationea pilot study. Transpl Int 2011;24:100-0.
[10]
Stock KF, Klein BS, Cong MT, Regenbogen C, Kemmner S, Buttner M, et al. ARFI-based tissue elasticity quantification and kidney graft dysfunction:first clinical experiences. Clin Hemorheol Microcirc 2011;49:527-75.
[11]
He WY, Jin YJ, Wang WP, Li CL, Ji ZB, Yang C. Tissue elasticity quantification by acoustic radiation force impulse for the assessment of renal allograft function. Ultrasound Med Biol 2014;40:322-2.
[12]
Guo LH, Xu HX, Fu HJ, Peng A, Zhang YF, Liu LN. Acoustic radiation force impulse imaging for noninvasive evaluation of renal parenchyma elasticity:preliminary findings. PLoS One 2013;8:e68925.
[13]
Bota S, Bob F, Sporea I, Sirli R, Popescu A. Factors that influence kidney shear wave speed assessed by acoustic radiation force impulse elastography in patients without kidney pathology. Ultrasound Med Biol 2015;41:1-1.
[14]
Syversveen T, Midtvedt K, Berstad AE, Brabrand K, Strom EH, Abildgaard A. Tissue elasticity estimated by acoustic radiation force impulse quantification depends on the applied transducer force:an experimental study in kidney transplant patients. Eur Radiol 2012;22:2130-0.
[15]
Tozaki M, Isobe S, Fukuma E. Preliminary study of ultrasonographic tissue quantification of the breast using the acoustic radiation force impulse (ARFI) technology. Eur J Radiol 2011; 80:e182-2.
[16]
Kaminuma C, Tsushima Y, Matsumoto N, Kurabayashi T, Taketomi-Takahashi A, Endo K. Reliable measurement procedure of virtual touch tissue quantification with acoustic radiation force impulse imaging. J Ultrasound Med 2011;30:745-51.
[17]
Yamanaka N, Kaminuma C, Taketomi-Takahashi A, Tsushima Y. Reliable measurement by virtual touch tissue quantification with acoustic radiation force impulse imaging:phantom study. J Ultrasound Med 2012;31:1239-94.
[18]
Potthoff A, Attia D, Pischke S, Kirschner J, Mederacke I, Wedemeyer H, et al. Influence of different frequencies and insertion depths on the diagnostic accuracy of liver elastography by acoustic radiation force impulse imaging (ARFI). Eur J Radiol 2013;82:1207-72.
[19]
Asano K, Ogata A, Tanaka K, Ide Y, Sankoda A, Kawakita C, et al. Acoustic radiation force impulse elastography of the kidneys:is shear wave velocity affected by tissue fibrosis or renal blood flow? J Ultrasound Med 2014;33:793-301.
[20]
Goertz RS, Amann K, Heide R, Bernatik T, Neurath MF, Strobel D. An abdominal and thyroid status with acoustic radiation force impulse elastometryea feasibility study:acoustic radiation force impulse elastometry of human organs. Eur J Radiol 2011;80:e226-60.
[21]
Lee MJ, Kim MJ, Han KH, Yoon CS. Age-related changes in liver, kidney, and spleen stiffness in healthy children measured with acoustic radiation force impulse imaging. Eur J Radiol 2013;82:e290-0.
[22]
Nightingale K, McAleavey S, Trahey G. Shear-wave generation using acoustic radiation force:in vivo and ex vivo results. Ultrasound Med Biol 2003;29:1715-53.
[23]
Cokkinos DD, Antypa EG, Skilakaki M, Kriketou D, Tavernaraki E, Piperopoulos PN. Contrast enhanced ultrasound of the kidneys:what is it capable of? BioMed Res Int 2013;2013:595873.
[24]
Jin Y, Yang C, Wu S, Zhou S, Ji Z, Zhu T, et al. A novel simple noninvasive index to predict renal transplant acute rejection by contrast-enhanced ultrasonography. Transplantation 2015; 99:636-69.
[25]
Harvey CJ, Sidhu PS, Bachmann Nielsen M. Contrast-enhanced ultrasound in renal transplants:applications and future directions. Ultraschall Med 2013;34:319-91.
[26]
Schwenger V, Korosoglou G, Hinkel UP, Morath C, Hansen A, Sommerer C, et al. Real-time contrast-enhanced sonography of renal transplant recipients predicts chronic allograft nephropathy. Am J Transplant 2006;6:609-95.
[27]
Benozzi L, Cappelli G, Granito M, Davoli D, Favali D, Montecchi MG. Contrast-enhanced sonography in early kidney graft dysfunction. Transplant Proc 2009;41:1214-4.
[28]
Grzelak P, Szymczyk K, Strzelczyk J, Kurnatowska I, Sapieha M, Nowicki M, et al. Perfusion of kidney graft pyramids and cortex in contrast-enhanced ultrasonography in the determination of the cause of delayed graft function. Ann Transplant Q Pol Transplant Soc 2011;16:48-83.
[29]
Schwenger V, Hankel V, Seckinger J, Macher-Goppinger S, Morath C, Zeisbrich M, et al. Contrast-enhanced ultrasonography in the early period after kidney transplantation predicts long-term allograft function. Transplant Proc 2014;46:3352-2.
[30]
Fernandez CP, Ripolles T, Martinez MJ, Blay J, Pallardo L, Gavela E. Diagnosis of acute cortical necrosis in renal transplantation by contrast-enhanced ultrasound:a preliminary experience. Ultraschall Med 2013;34:340-0.
[31]
Wilson SR, Burns PN. Microbubble-enhanced US in body imaging:what role? Radiology 2010;257:24-49.
[32]
Perrella RR, Duerinckx AJ, Tessler FN, Danovitch GM, Wilkinson A, Gonzalez S, et al. Evaluation of renal transplant dysfunction by duplex Doppler sonography:a prospective study and review of the literature. Am J Kidney Dis 1990;15:544-40.
[33]
Kocabas B, Aktas A, Aras M, Isiklar I, Gencoglu A. Renal scintigraphy findings in allograft recipients with increased resistance index on Doppler sonography. Transplant Proc 2008; 40:100-0.
[34]
Schwenger V, Keller T, Hofmann N, Hoffmann O, Sommerer C, Nahm AM, et al. Color Doppler indices of renal allografts depend on vascular stiffness of the transplant recipients. Am J Transplant 2006;6:2721-1.
[35]
Stenberg B, Chandler C, Wyrley-Birch H, Elliott ST. Postoperative 3-dimensional contrast-enhanced ultrasound (CEUS) versus Tc99m-DTPA in the detection of post-surgical perfusion defects in kidney transplants-preliminary findings. 2014;35:273-3.
[36]
McArthur C, Baxter GM. Current and potential renal applications of contrast-enhanced ultrasound. Clin Radiol 2012;67:909-92.
[37]
Inoue T, Kozawa E, Okada H, Inukai K, Watanabe S, Kikuta T, et al. Noninvasive evaluation of kidney hypoxia and fibrosis using magnetic resonance imaging. J Am Soc Nephrol 2011;22:1429-94.
[38]
Kaul A, Sharma RK, Gupta RK, Lal H, Jaisuresh, Yadav A, et al. Assessment of allograft function using diffusion-weighted magnetic resonance imaging in kidney transplant patients. Saudi J Kidney Dis Transplant 2014;25:1143-3.
[39]
Yang D, Ye Q, Williams DS, Hitchens TK, Ho C. Normal and transplanted rat kidneys:diffusion MR imaging at 7 T. Radiology 2004;231:702-2.
[40]
Park SY, Kim CK, Park BK, Kim SJ, Lee S, Huh W. Assessment of early renal allograft dysfunction with blood oxygenation leveldependent MRI and diffusion-weighted imaging. Eur J Radiol 2014;83:2114-41.
[41]
Xiao W, Xu J, Wang Q, Xu Y, Zhang M. Functional evaluation of transplanted kidneys in normal function and acute rejection using BOLD MR imaging. Eur J Radiol 2012;81:838-85.
[42]
Neugarten J, Golestaneh L. Blood oxygenation leveldependent MRI for assessment of renal oxygenation. Int J Nephrol Renovasc Dis 2014;7:421-15.
[43]
Heusch P, Wittsack HJ, Blondin D, Ljimani A, Nguyen-Quang M, Martirosian P, et al. Functional evaluation of transplanted kidneys using arterial spin labeling MRI. J Magn Reson Imaging 2014;40:84-4.
[44]
Lanzman RS, Ljimani A, Pentang G, Zgoura P, Zenginli H, Kropil P, et al. Kidney transplant:functional assessment with diffusion-tensor MR imaging at 3T. Radiology 2013;266:218-85.
[45]
Bashir MR, Jaffe TA, Brennan TV, Patel UD, Ellis MJ. Renal transplant imaging using magnetic resonance angiography with a nonnephrotoxic contrast agent. Transplantation 2013; 96:91-1.
Christopher Hartman, Nikhil Gupta, David Leavitt, David Hoenig, Zeph Okeke, Arthur Smith. Advances in percutaneous stone surgery[J]. Asian Journal of Urology, 2015, 2(1): 26
-32
.
